抄録
It is known that INH has side effect for skin, gastro-intestinal organs, hematopoetic tissue and peripheral nervous system. There are no prominent side effect within the dosis of 4 to 8mg/kg except slight headache, dizziness, thirst, exaggeration of tendon reflexes, sensory disturbances and constipation. There are some reports of CNS involvement with experimental animals, but there is few in human, which is only reported by Glaubitz and Shiozaki et al.
This case is a thirty-two-years-old male. During his admission with pulmonary and laryngeal tuberculosis he had much headache, vomitting and fever. He could not take INH per os anymore, then switched to INH injection (100mg) every day. Several hours later he had frequent epileptic seizure, on some day he had about fourty times of grand mall. Besides he had hallucination and delusion especially at evening and night. After cessation of the injection of INH still he had psychotic state in following several months, then appeared affect disturbance (mostly apathetic and euphoric), disorientation and dementia. At present, three years after intoxication, still he has dementia and personality change.
This case is a severe INH intoxication of the central nervous system with status epilepticus and symptomatic psychosis, and later on he showed personality change and dementia.
