Abstract
It is said that the marked advances was made in diagnosis of SLE since LE cells phenomenon was discovered by Hargraves in 1948. LE cells phenomenon is a important factor in making diagnosis of SLE.
There are many diagnostic criterias in SLE by famous authors and Committees, for instances-by Stevens, Dubois, MRC and ARA. Among these, there are some differences, that is, like Dubois' criteria some signs and items have larger weight and like criteria of ARA all signs and items have same weight for diagnosis of SLE.
This paper was described in the attempt to discuss whether LE factor would have same or larger weight in the all items of criteia. 45 cases of positive LE test (Hyland Co. ) and 105 cases of negative LE test were picked up at random in collagen diseases, liver diseases, renal diseases, blood diseases, allergic and so on.
Then the results were obtained as follows-
1) LE test was positive in about 80% of cases of definite SLE and in about 70% of cases in definite and suspected. In the other diseases there was no cases that LE test was positive over 50%, and LE test was positive in 20-30% in liver diseases, tbc., PSS, and so on.
2) LE cells was positive in about half cases of SLE and in rare cases of the other diseases. In SLE about 60% of cases of positive LE test revealed positive LB cells phenomenon and in others only one cases of positive LE that revealed positive LE cells phenomenon. In SLE one of negative LE test was positive LB cells and in others all of negative LE test was not negative LE cells. Then positive relationship between LE test and LE cell phenomenon was recognized and LE test was more sensitive and less specific than LB cell phenomenon for making the diagnosis of SLE.
3) In the cases of positive LE test, higher titers of B. S. R., rather leucopenia, more positive RA test and higher titer of γ-Glob, were recognized. But the factor made positive LB test was not discussed.
4) In making the diagnosis of SLE typical skin rash and LB factor etc, may be supposed to be rather more important
