Abstract
The suthors has reported a part of the present study at the 38th and 39th meetings of the Japanese Gastro-enterological Society. In that report, the authors asserted that the hook worm must be divided into two classes, i. e., Necator americanus and Ancylcstoma Dubini. In this paper, several items such as changes of gastric juice, correlation between gastric juice, anemia, worm excretion and pituitary adreno-cortical system, and consequence of anthelmin treatment.
20 cases diagnosed as ancylostomiasis Dubini were investigated reagrding to their gastric juice obtained by the Katsch-Kalk's method. They were also examined with respect to blood picture and pituitary-adrenc-cortical system's function. For the anthelmin, tetra-chlor-aethylen was administered 2 or 3 series at the intervals of four days. The worms were examined by all feces of all cases. Complete excretion of worm was judged by the suspension method and culture method which were employed three times at the second week from the last anthelmin administration.
Achylia was found in 13 cases and hypo chylia in 3 cases. As for total acidity, there were 12 cases of hypo-chylia and 8 normal cases. As for maximum free acidity by the administration of the medicine, there were 7 cases of hypo-chylia, 8 normal cases and 5 cases of hyper-chylia. As for the time of dye excretion, there were 12 normal cases, 6 cases of prcmptitude and 6 cases of delayed excretion As for acidulous curve, there were 7 cases of normal curve, 6 cases of flat curve, 4 cases of delay curve, 3 cases of accelerated curve and no cases of continuous curve or gradual curve. There were many cases of hypo-acidity without any relation to the degree of their anemia. This may be derived from the fact that most of the cases were anemia of slight degree. In cases of slight anemia, the maximum free acidity was normal level or greater by the injection. There were no relations between anemia and the time to reach at the maximum acidity or the acidulous curve. Incidentally, in case of slight anemia, time of dye excretion was generally delayed. There were no relation between worm excretion and hunger acidity, maximum acidity, and the time to reach the maximum acidity. No relation were found between worm excretion and acidulous curve. Cases of which ecsinophil cell increase was greater than 11%, had low acidity. There were no relation between % of eosinophil cell and the time for excretion or acidity curve. No distinct correlations were found between pituitary adreno-cortical system function and gastric juice.
As for the effects of anthelmin, 4 cases showed increase of acidity, 8 cases showed more or less favorable outcome. 4 cases showed low acidity by anthelmin and they were more than 45 of age. Relation between the acidity and anemia was not distinct. The last result will not agree with the former study. It is supposed that hydo-acidity may be seen in case of remarkable hypereosinophilia. Result of Thorn's test gave no relationship between acidity and pituitary-adreno-cortical system. It is supposed that not only worm excretion but also age, term of infection, disposition etc. are related to the degree of acidity.
