抄録
The bacteriocidal activities of INAH, DSM, PAS, TB1, Cepharanthin, Vitamin K, Z-Furan, Monafuracin, Guanofuracin, Protomin, Protozol, Diazone and Neo-Minophagen A. T. against H37RV strain of M. Tuberculosis were investigated. Results obtained were as follows:
1) H37RV were immersed into each drug at various degree of density for 1, 24 and 48 hours, and cultivated in the Oka-Katakura media, and washing off treatment was applied. Charts were prepared to record the densities which completely or imcompletely killed the bacilli. The result showed that INAH was the strongest one.
2) H37RV were immersed into INAH, DSM, PAS, TB1 and Vitamin K respectively, for 1, 24 and 48 hours (washing off treatment according to Sasano's Method was applied), and planted upon Oka-Katakura media. Bacteriocidal density of drugs was generally higher than in case of the experiment No. 1. INAH, TB1 and Vitamin K gave bacteriocidal results, while DSM and PAS did not at all. By this experiment, using both Proskauer-Beck culture media and Oka-Katakura media, we found that the bacteriocidaj effects of each drug were stronger in the former culture media than in the latter media. DSM and PAS also showed bacteriocidal effects, though insignificant, in Proskauer-Beck culture media. INAH showed the strongest effect.
3) If the bacilli were immersed into INAH, DSM, PAS and TB1, respectively, for 1 week, 2, 3 and 4 weeks, they were killed even in comparatively dilute density.
4) According to our experiments, the results seemed to be depndent more or less, on the culture media employed. For example, the results obtained in Proskauer-Beck media were higher values than in case of Oka-Katakura media. DSM hardly showed bacteriocidal effect, when the quantity of bacilli were large.
