細菌性赤痢の化學療法剤使用後における腸内菌叢の變動について

抄録

Among the bacillary dysentery cases treated with tetracycline, 57 cases, whose stool was tested to be of large number of cocci especially staphylococci, were selected and were studied in order to know the changes in the intestinal bacterial flora and their relationship to the character of stool. The staphlococci, enterococci and proteus organisms isolated from them were subjected to the examination of drug-resistances.
1.) The presence of many Gram-positive cocci in remarkable decrease or absence of Gram-negative rods in stool was observed in patients during the period of drug-administ-ration and within 2 days after the cessation of the chemotherapy. Later on, gradual decrease of cocci and increase of proteus or coli group organisms were observed, and finally the coli group organisms predominated in number.
2) Seasonal change in the occurrence of proteus group was observed; i. e., among 31 cases, in which proteus appeared in stool, continuous presence of the proteus for 4 months. from July to October was observed in 29 cases.
3) There, seemed to be no relationship between changes in the intestinal bacterial flora and the character of stool in the light of the fact that pathologic stool character was observed in 42 cases out of 57, in every stages of bacterial floral changes.
4) Symptoms due shifts in intestinal bacterial flora were not manifested in the cases reported herein, but the fact, that the organisms isolated from our cases were shown to be resistant to various antibiotics, would suggest the difficulties of chemotherapy when these symptoms are encountered.