Inteins in action

Francine B. Perler; Maurice W. Southworth; Lear Brace

doi:10.11490/isea.2005.0.124.0

International Symposium on Extremophiles and Their Applications 2005

DOI https://doi.org/10.11490/isea.2005.0.124.0

会議情報

主催: Japan Agency for Marine-Earth Science and Technology

共催: Toyo University, Japan Society for the Promotion of Science

Genetics and Protein Functions II

Inteins in action

*Francine B. Perler, Maurice W. Southworth, Lear Brace

著者情報

キーワード: Intein, protein splicing, mechanism, gene conversion, homing endonuclease

会議録・要旨集フリー

p. 124-130

詳細

抄録

The mechanism of intein-mediated protein splicing was first described using an intein from a Pyrococcus species. Inteins are sporadically dispersed amongst the various phyla. Inteins are often encoded by mobile genetic elements that allow them to be horizontally transferred. Inteins naturally lacking the standard amino-terminal nucleophile can still splice by a slightly different mechanism. Understanding the mechanism of protein splicing has allowed scientists to harness inteins for numerous bioorganic chemistry and biotechnology application

責任著者(Corresponding author)

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