抄録
The Mrp family of monovalent cation/proton antiporters is widespread among prokaryotes, and its members possess characteristics that make this class of antiporters unique. These include a requirement for 6-7 genes for full function, in comparison to all previously characterized bacterial monovalent cation/proton antiporters which are single gene products. Characterization of the unusual properties of Mrp-dependent antiport will lead to an understanding of how this system is able to support growth at extremely high pH. We are completing a comparative analysis of the activity profiles of the alkaliphile Mrp system and that of B. subtilis and other non-extremophiles. The results suggest significant commonalities among several members of this conserved family of antiporters.
