A 4M-pixel Charge Modulation Device (CMD) image sensor with pixel size of 7.5×7.5μm^2 has been developed. The sensor has three readout modes that are a full, a skip and a block modes. A 4M-Pixel image is obtained in the full modes, while an arbitrary window-of-interest can be read out in the block modes. The skip mode reads every 4th pixel in both horizantal and vertical directions. The frame rate can be raised in the skip and the block modes. The sensor also has a capability of lowering the dark current generation during the integration time.