Effects of excess administration of vitamin D on the changes in aging of phospholipids of rat salivary glands

Abstract

In order to know the effects of excess administration of vitamin D on parotid glands and submandibular glands of rats, changes in phospholipid compositions were investigated using the 3 and 12-month rats. In parotid glands of the 12-month rats, lipid phosphorus per unit wet weight of glandular tissue increased, and the proportions of palmitic, linoleic and arachidonic acid increased markedly, however, those of palmitoleic and oleic acids decreased in phosphatidylethanolamine fractions. On the other hand, in submandibular glands, phosphorus per unit wet weight of glandular tissue of phosphatidylethanolamine and phosphatidylcholine fractions decreased both 3 months to 12 months of age. The proportions of palmitic acid increased but oleic and linoleic acid decreased in phosphatidylcholine fraction of submandibular glands of the 3-month rats. Thus, it seems evident that there are differences in effects of vitamin D on parotid and submandibular glands of rats in young or old age, respectively.