1981 Volume 6 Issue 1 Pages 25-32
In the last 3 years, we have performed combination cancer therapy in 7 primary cases of mandibular gingival cancer which involve the lower portion of the mandible by the following regimen: pepleomycin, 5-10 mg intra-arterially (I. A.) or I. V. daily up to a total dose of 30-50 mg, or 5-fluorouracil at 125-250 mg I. A. once daily up to a total of 750-1500 mg’, external 60Co radiation at 200 rads once daily up to a total of 1000-1600 rads, for 5-8 preoperative days. From one to five days following this treatment, thorough removal of cancer tissues of the tumorous region was performed in combination with a peroral partial resection; i.e., radical thorough removal of cancer tissues. In all but one case, which was terminated due to another cause, favorable results were achieved so that the shape and function of the mandibular portion of the face was well retained. All patients were rehabilitated orally.
