In order to know the effects of excess administration of vitamin D on parotid glands and submandibular glands of rats, changes in phospholipid compositions were investigated using the 3 and 12-month rats. In parotid glands of the 12-month rats, lipid phosphorus per unit wet weight of glandular tissue increased, and the proportions of palmitic, linoleic and arachidonic acid increased markedly, however, those of palmitoleic and oleic acids decreased in phosphatidylethanolamine fractions. On the other hand, in submandibular glands, phosphorus per unit wet weight of glandular tissue of phosphatidylethanolamine and phosphatidylcholine fractions decreased both 3 months to 12 months of age. The proportions of palmitic acid increased but oleic and linoleic acid decreased in phosphatidylcholine fraction of submandibular glands of the 3-month rats. Thus, it seems evident that there are differences in effects of vitamin D on parotid and submandibular glands of rats in young or old age, respectively.

In the last 3 years, we have performed combination cancer therapy in 7 primary cases of mandibular gingival cancer which involve the lower portion of the mandible by the following regimen: pepleomycin, 5-10 mg intra-arterially (I. A.) or I. V. daily up to a total dose of 30-50 mg, or 5-fluorouracil at 125-250 mg I. A. once daily up to a total of 750-1500 mg’, external ⁶⁰Co radiation at 200 rads once daily up to a total of 1000-1600 rads, for 5-8 preoperative days. From one to five days following this treatment, thorough removal of cancer tissues of the tumorous region was performed in combination with a peroral partial resection; i.e., radical thorough removal of cancer tissues. In all but one case, which was terminated due to another cause, favorable results were achieved so that the shape and function of the mandibular portion of the face was well retained. All patients were rehabilitated orally.

The purpose of this study was to determine the effects of the voluntary exercise using EMG biofeedback mechanism for the patients who have had difficulty of jaw opening after surgical treatment of oral tumors. Five patients were selected from prosthodontics department in Iwate Medical university those of whom have had hard trismus due to scar and atrophy of muscles.

Auditory and visual EMG feedback mechanism were applied to voluntary muscles excercise.

The following results were obtained:

1. All over patients were recovered the jaw opening up-to 20mm.

2. Although, the radiotherapy and surgical procedure may effect the degree of jaw opening.

3. It is recognized that comprehension and cooperation of patient attitude for this excercise and term of excercise may be effected.

Submandibular gland specimens from thirty-sevell patients evaluated for the chronic sialadenitis were examined histologically and histometrically. Histopathologically, the chronic sialadenis was classified into 2 types, i. e., the focal sialadenitis and the diffuse sialadenitis. The diffuse sialadenitis was also subclassed into cellular type and fibrous type. The focal sialadenitis occupied 10.8% in 37 cases of the chronic sialadenitis; cellular type of the diffuse sialadenitis occupied 37.8% and fibrous type of it occupied 51.4% of the chronic sialadenitis Many fibrous types of the diffuse sialadenitis were caused by the sialolith and the radiation for a therapy of the oral cancer. The histometric study demonstrated that a change of pyroninophilic plasma cell proportions with increasing the number of infiltrating mononuclear cells in the area of 240×240μ²/3μ showed a little difference between the cellular type and fibrous type of diffuse sialadenitis.

Moreover, the histometric change of the distribution of the acini with increasing the number of infiltrating mononuclear cells in 240×240μ²/3μ suggested that the degeneration and/or destruction of acinar cells occurred in the early stage of lesions of the chronic sialadenitis. Plasma cells frequently accumulated among the acini and the proportion of pyroninophilic plasma cells in the areas containing a small number of infiitrating mononuclear cells was reiatively a high percentage in the diffuse sialadenitis. These suggest that plasma cells may have some significant roles in the development of lesions of the chronic sialadenitis

The inhibitory effect of NaF on dopamineβ-hydroxylase (DβH) activity was examined to clarify influence of fluorides on the function of a living body. DβH was prepared from bovine adrenal glands by modifying the method of Friedman and Kaufman, and DβH activity was assayed according to the method of Van der Schoot et al., NaF at 10 mM concentration inhibited 40% of DβH activity. This inhibition by NaF was recovered by dialysis for 12 hrs, but not by the addition of Cu⁺⁺ to the reaction mixture. Regardless of the presence of NaF, the increase of the enzymatic formation of octopamine from tyramine was almost linear with respect to the incubation time (up to 20 min) and there was positive correlation between the increase of the enzymatic formation of octopamine from tyramine and enzyme concentration (up to 60μg protein). Furthermore, the inhibitory effect of NaF on DβH activity increased with the prolongation of preincubation time. Kinetic studies using the Lineweaver-Burk plot revealed that this inhibitory effect of NaF was of a noncompetitive type with the substrate, tyramine and ascorbic acid, one of the cofactors in this reacion. These results indicate that NaF produces reversible inhibition of DβH activity probably by combining directly with DβH molecules.

A case of a retroesophageal right subclavian artery and the right vertebral artery arising from the right common carotis artery was reported. This case was found in a 71-year-old female during dissecting at Iwate Medical University in 1980.

From the aortic arch with normal course, the following branches arose: the right common carotid artery, the left common carotis artery, the left subclavian artery and the right subclavian artery as the last branch. The last anomalous artery originated from the dorsal wall of the aortic arch and ran vertically to the right behind the esophagus at the third thoracic vertebra. The right vertebral artery entered the transverse foramen of the 5 th cervical vertebra.

This case may be classified as G-type by Adachi-Williams-Nakagawa and the figure 4 according to Holzapfel. This is the 5 th case in Japanese cadavers.

Clinical observation was made for a patient who had complete maxillectomy and wearing a sectional prosthesis using samarium-cobalt magnets for obtaining retention.

The following result can be made according to the clinical observation after wearing prosthesis.

1. It was easily to insert a sectional prosthesis and obturator was to improve the speech function remarkably.

2. Complete denture could be made in usual manner and was useful to the mitigate patients psychological being caused by、characteristic from of maxillary prosthesis.

3. Samarium-cobalt magnet was effective for retaining the prosthesis of obturator and complete upper denture. However, protecting the rust of magnet was questionable whereas in the oral cavity.