Abstract
The Correlation between the affinity of mold with 9-straight chain alkylated acridine derivatives and the antifungal activity was examined with an electrochemical method, cyclic voltammetry. 9-Methylacridine (MeAc), 9-ethylacridine (EtAc), 9-n-propylacridine (PrAc), 9-n-butylacridine (BtAc), 9-n-pentylacridine (PnAc), 9-n-hexylacridine (HxAc), 9-n-heptylacridine (HpAc) and 9-n-octylacridine (OcAc) were employed as the 9-straight chain alkylated acridine derivatives and Aspergillus niger was used as mold. The cyclic voltammograms (CVs) of the derivatives were measured using a mold-covered Pt plate electrode. The reversible redox current peaks due to the generation-disappearance of the anion radicals of the derivatives were observed in all the CVs. The adsorption current peaks significantly appeared in the CVs of PnAc. Furthermore, the reversible redox current peaks were directly proportional not to the square root of the scan rate, but to the scan rate. This meant that PnAc was adsorbed by the mold. Judging from the fact that PnAc has the highest antifungal activity, the adsorption of the 9-straight chain alkylated acridine derivatives to the mold was an important factor for the antifungal activity.
