Many studies have demonstrated that children and adolescents with epilepsy have more emotional, social, and behavioral problems than their healthy peers. The present case study reports Cognitive Behavior Therapy with Problem-solving Therapy and Social Skills Training for an adolescent with juvenile myoclonic epilepsy. Assessment of her frequent seizure in school indicated that they were related to stress and anxiety in social situations, which were caused by her low problem-solving skills, low social skills and negative self-evaluation. Cognitive Behavioral Therapy was effective for decreasing seizure frequency and stress reactions in this person. We have discussed the effects of Cognitive Behavior Therapy in children with epilepsy.