Abstract
Recently, hospitals have not only been diagnosing congenital diseases by analyzing platelets, but also evaluating the therapeutic effect of anti-platelet drugs through the platelet aggregation test. In our hospital, we evaluate the effect of anti-platelet drugs on the basis of Grade Type (G-Type) through four concentration analysis indexes installed in the semi-automated platelet aggregation analyzer PRP313M. At this time, the new analysis index of platelet aggregation (platelet aggregation level; PAL) was developed and installed in the automated blood coagulation analyzer CS-5100. We evaluated the usefulness of adenosine diphosphate (ADP)-induced PAL (APAL) and collagen-induced PAL (CPAL) by comparing them with the G-Type of each reagent. The correlation coefficients were r = 0.72 for APAL with G-Type and r = 0.71 for CPAL with G-Type. We separated the samples into two groups by our usual cutoff G-Type of −1. The distribution results of APAL and CPAL showed significant differences between groups. Moreover, an APAL of 7.1 and a CPAL of 8.0 were equivalent to a G-Type of −1 and the concordance rates of evaluation based on APAL and CPAL were 92.6% and 86.0%, respectively. From these results, we consider that we can evaluate the effect of anti-platelet drugs on the basis of PAL as well as G-Type. Furthermore, because CS-5100 is an automated blood coagulation analyzer for general coagulation tests, it enables hospitals that do not have a special analyzer for the platelet aggregation test to evaluate the effect of anti-platelet drugs.
