2020 Volume 69 Issue 4 Pages 623-630
Primary aldosteronism (PA) is the most frequent cause of secondary hypertension, and PA could result in organ injuries. Therefore, it is necessary to diagnose PA in individuals with hypertension. The ratio of aldosterone to renin is used for the screening for PA. However, since the measurements of aldosterone and renin levels are usually performed by an RIA method, they are not commonly performed in hospital laboratories. In this study, we evaluated the basic performances and the possible usefulness of Accuraseed, which is a fully automated chemiluminescent enzyme immunoassay machine (from FUJIFILM Wako Pure Chemical Corporation), for ARC and aldosterone measurements. We obtained favorable results of within-run and between-day precision tests, linearity tests, and interference tests. We also observed good correlations between measurements using Accuraseed and other methods (an EIA method for ARC and an RIA method for aldosterone). However, we should carefully interpret the results for renin because measurement tools are different between ARC and plasma renin activity (PRA).
