EFFECTS OF SOME TRANQUILIZING DRUGS UPON SHOCK-MOTIVATED ESCAPE RESPONSE IN RATS
1966 年 16 巻 2 号 p. 75-85
詳細
1966 年 16 巻 2 号 p. 75-85
Effects of two tranquilizers (CPZ, and homofenazine) upon shock-motivated behavior were studied as a function of the dose level (saline, 1, 2, 4, and 8 mg/kg, i. p.) and time after injection (0, 15, 30, 60, and 120 min.) with male rats satiated with food and water. CPZ was found to retard both starting and running time as an increase in dose level, and the same motor effect was maximal around 30 min. after injection under each dosage.
On the other hand, no obvious dose-, nor time-response relationships were observed with the homofenazine-injected rats with respect to running time. Starting time was only slightly depressed by 8 mg/kg of homofenazine, and the time-response relationship in terms of starting time was not significant. However, conditioned avoidance response without electric shock was found to be depressed by homofenazine as an increasing function of dosage level. Thus it was hypothesized that the ataxic effect of homofenazine or the drug in general is a function of arousal level of the drugged animal.
