主催: 日本学術会議 「機械工学委員会，土木工学・建築学委員会合同IUTAM分科会」
共催: 応用物理学会, 化学工学会, 自動車技術会, 地盤工学会, 土木学会, 日本応用数理学会, 日本風工学会, 日本機械学会, 日本気象学会, 日本計算工学会, 日本計算数理工学会, 日本建築学会, 日本原子力学会, 日本航空宇宙学会, 日本混相流学会, 日本地震工学会, 日本数学会, 日本船舶海洋工学会, 日本伝熱学会, 日本物理学会, 日本流体力学会, 農業農村工学会
Tissue morphogenesis can be controlled by the coupling between biochemical and mechanical signals to derive the functional three-dimensional (3D) shapes of organs. To acquire a better understanding of the mechano-chemical coupling, we construct a mathematical model based on the understanding of the physical picture of ligand–receptor kinetics at the 3D cell surface. Simulations demonstrated that the coupling between the gene expression and cell shape occurs spontaneously to regulate the spatiotemporal gene expression at the tissue scale, indicating that the cell shape is a key regulatory link between multi-physical events or multi-scale phenomena at the subcellular and tissue scales.
