理論応用力学講演会 講演論文集
第64回理論応用力学講演会
セッションID: OS2-01-02
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OS2-1 マルチスケール・マルチフィジックス熱流体工学の最前線(1)
形態形成における力学―生化学連成の数理モデル
井上 康博安達 泰治
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会議録・要旨集 フリー

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Tissue morphogenesis can be controlled by the coupling between biochemical and mechanical signals to derive the functional three-dimensional (3D) shapes of organs. To acquire a better understanding of the mechano-chemical coupling, we construct a mathematical model based on the understanding of the physical picture of ligand–receptor kinetics at the 3D cell surface. Simulations demonstrated that the coupling between the gene expression and cell shape occurs spontaneously to regulate the spatiotemporal gene expression at the tissue scale, indicating that the cell shape is a key regulatory link between multi-physical events or multi-scale phenomena at the subcellular and tissue scales.

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