Transformative change with digital transformation (DX) is the key to achieving a sustainable global society towards 2030 as the milestone year and 2050 as the goal year. This paper introduces applications of digital technologies to achieve the Sustainable Development Goals (SDGs), defined by the United Nations as goals to achieve by 2030, and discusses a perspective of the fusion of physical space and cyberspace. In the background, the paper considers the importance of “the decade of action” from the viewpoint of the SDGs as well as our response to climate change and biodiversity conservation. In Chapter 2, the “Platform Clover,” an SDGs knowledge platform, is introduced, and two applications of artificial intelligence-related technology are explained to share the importance of understanding and sharing the SDGs nexus structure. In the final chapter, imaginative perspectives towards 2050 are discussed, reaching beyond the SDGs era. We must make transformative change to the Society 5.0 world by deploying the power of digital technology, and the decision about how to integrate physical and cyberspace by digital technology is the underlying key to success in the globally aging period from 2030 to 2050 period.