2012 年 10 巻 2 号 p. 77-81
Apoptosis of cardiomyocytes plays an important role in the development of cardiovascular diseases (CVD). Numerous of studies have investigated the relationship between periodontal and CVD, particularly myocardial infarction (MI) and stroke. Pathological sympathetic overactivation and vagal withdrawal are thought to reduce the survival rate after acute MI (AMI) and chronic heart failure. Recent studies also suggested that acetylcholine (ACh), a parasympathetic nerve system neurotransmitter, on the gap junction component connexin43 (Cx43) using H9c2 cells. We tested whether exogenous of ACh improved the H2O2-induced death of H9c2 cell. In this study, H2O2-induced H9c2 cardiomyoblasts death was not were improved by ACh (10, 100, 1000 μM). These results suggest that the ACh is not involved in the H2O2-induced death of H9c2 cell.