Journal of Oral Tissue Engineering
Online ISSN : 1880-0823
Print ISSN : 1348-9623
ISSN-L : 1348-9623
ORIGINAL ARTICLES
Influence on the Long-term Differentiation Culture of ES-D3 Cells with String-like Collagen Scaffolds Derived from Tilapia Scales
Koichi IMAITetsunari NISHIKAWAShosuke MORITATomio ISEKIHiroaki YOSHIDAKazuhiro MATSUMOTOMuneyasu SHIDAFumiya OGAWAKazuhiko SUESE
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2015 年 13 巻 3 号 p. 125-130

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In the field of regenerative medicine, tissues and organs differentiated from iPS cells are implanted into the body. For this purpose, scaffolds using collagen derived from fish, evolutionarily distant from humans, are safer than those using mammalian (porcine) collagen. In the present study, the differentiation of mouse-derived ES cells was examined using string-like porous collagen derived from tilapia that inhabits tropical and subtropical regions. Cell differentiation into bone or cartilage requires 30-day culture. Whether or not the string-like collagen could withstand the long-term culture was examined, demonstrating that 86% of the collagen retained a gel form during the culture without any effect on ES cell differentiation.

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© 2015 by Japanese Association of Regenerative Dentistry
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