2016 年 14 巻 1 号 p. 65-69
The purpose of this study was to evaluate the effects of aging on bone formation induced by Bone Morphogenetic Protein-2 (BMP-2) using low-intensity pulsed ultrasound (LIPUS)in 12-week-old (12w group) and 70-week-old (70w group) Wistar rats.
The experimental sites (palatal subperiosteal sites) were divided into three sites as follows: BMP site, BMP-2 was implanted; LI-BMP site, LIPUS treatment was performed every three days after implantation of BMP-2; and Control site, neither implantation of BMP-2 nor LIPUS treatment was done.
At 3 weeks after surgery, thickness of new bone (TNB) was significantly higher in both the BMP and LI-BMP sites than in the Control site (P<0.05). TNB of every site in the 12w group was significantly higher than that of the same experimental site in the 70w group (P<0.05). Newly formed bone was almost integrated with original bone at the LI-BMP site.
These results suggest that LIPUS enhances the maturation of bone formation induced by BMP-2 even in senescent rats, although the volume of bone decreased with aging.