Journal of Oral Tissue Engineering
Online ISSN : 1880-0823
Print ISSN : 1348-9623
ISSN-L : 1348-9623
ORIGINAL ARTICLES
Study on Bone Formation Induced by Recombinant Human BMP-2 at Palatal Sites in Adult Rats
Kozo YAMAJIToshiyuki ITOTAShunji IZAWAYoshihiro NISHITANIMasahiro YOSHIYAMA
著者情報
キーワード: bone formation, rhBMP-2, adult rat
ジャーナル フリー

2006 年 4 巻 1 号 p. 37-42

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抄録

This study was designed to examine the effects of bone formation induced by recombinant human BMP-2 (rhBMP-2), which was implanted together with a poly-lactate-polyglycolate-copolymer/gelatine sponge (PGS) at palatal sites in 30-week- old male Wister rats. The rats were divided into four groups according to the dose of rhBMP-2: 0µg, 4µg, 8µg and 16µg.
New bone formation was observed in every group, and new bone was continuous with the original bone at 6 weeks after implantation. Thickness of new bone (TNB) increased as the dose increased from 0µg to 8µ, reached the maximal level at 8µg. In contrast, TNB decreased significantly as the dose increased from 8µg to 16µg.
The results of this study indicate that new bone formation varies according to the dose of rhBMP-2 at palatal sites in adult rats.

著者関連情報
© 2006 by Japanese Association of Regenerative Dentistry
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