2006 年 4 巻 1 号 p. 37-42
This study was designed to examine the effects of bone formation induced by recombinant human BMP-2 (rhBMP-2), which was implanted together with a poly-lactate-polyglycolate-copolymer/gelatine sponge (PGS) at palatal sites in 30-week- old male Wister rats. The rats were divided into four groups according to the dose of rhBMP-2: 0µg, 4µg, 8µg and 16µg.
New bone formation was observed in every group, and new bone was continuous with the original bone at 6 weeks after implantation. Thickness of new bone (TNB) increased as the dose increased from 0µg to 8µ, reached the maximal level at 8µg. In contrast, TNB decreased significantly as the dose increased from 8µg to 16µg.
The results of this study indicate that new bone formation varies according to the dose of rhBMP-2 at palatal sites in adult rats.