2006 年 4 巻 1 号 p. 32-36
The effect of hypothyroidism induced by thiamazole on the toxicity of fluconazole was studied in chick embryos. To our knowledge, no information is now available on the effects of thyroid gland function on the regeneration and differentiation of tissue. Fertilized eggs of White Leghorns were incubated and investigated. 1.2 mg/0.2 mL/egg of thiamazole was injected into the albumen of fertilized eggs on the 9th day of incubation. Fluconazole at 0.4 mg/egg was injected into the air sac of fertilized eggs on the 16th day of incubation. Electrocardiograms were recorded 0 to 60 min after the injection. After the injection of fluconazole into the thiamazole-treated eggs, the heart rate was significantly decreased compared with the untreated eggs. These findings indicate that hypothyroidism induced by thiamazole has a marked influence on the toxicity of fluconazole in chick embryos.