2007 年 4 巻 3 号 p. 117-120
Bone regeneration is accompanied by a cascade of events. Migration and proliferation of osteogenic cells occurred at the early stage of bone regeneration, and these osteogenic cells are involved in the synthesis of the bone matrix and its mineralization depending on their maturation stages. The remodeling of fracture callus is a crucial event that restores mechanical integrity and integrates the newly formed bone into the preexisting skeletal structure. Various molecules are involved in these processes to achieve complete bone healing, but the molecular mechanism underlying these processes has not been fully understood. To develop biology-based regenerative medicine/dentistry, we conduct BONE REGENERATION PROJECT by investigating molecular mechanism of osteoblast differentiation and bone regeneration. I will present some results from this project.