Effects of Application of Hyaluronan on Titanium Screw Mini-implants in the Cortical Bone of Dog Femurs

抄録

Hyaluronic acid is a biological material thought to facilitate cell migration, proliferation, and tissue repair in vitro. This study biomechanically evaluated the effect of hyaluronic acid on the quality of bone repair around pure titanium implants inserted into pre-drilled cavities measured on the basis of removal torque strengths.
Methods: Screw-shaped pure titanium mini-implants (measuring 6 mm in length and 1.2 mm in diameter), which had been developed for orthodontic use, were placed with and without hyaluronic acid into 1.0-mm and 1.2-mm-diameter pre-drilled cavities of the bilateral hind leg femurs of beagle dogs, aged 3 years, who had been anesthetized by the intravenous injection of sodium pentobarbital. At 3, 6, and 9 weeks post-insertion, biomechanical evaluations, which were made according to the removal torque strengths, were performed.
Results: The differences in the removal torque strengths between the implants with and without hyaluronic acid and controls at 3, 6, and 9 weeks after the operation were not significant.
Conclusions: Although these results did not indicate that hyaluronic acid itself markedly contributes to strengthening the interface between the implant and bone at an earlier stage, these findings did suggest that it may be useful as an exogenous matrix that can be added to various bioactive substances around the implant-tissue interface.