JARI Research Journal
Online ISSN : 2759-4602
Research Report
Effects of Exposure to Secondary Organic Aerosols Generated from Toluene and Xylene on Human Airway Epithelial Cells
Junichi HOSOYAHiroyuki HAGINOTsuyoshi ITO
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RESEARCH REPORT / TECHNICAL REPORT FREE ACCESS

2017 Volume 2017 Issue 6 Article ID: JRJ20170603

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Abstract
In order to understand the effect of secondary organic aerosols (SOAs) on induction of oxidative stress and inflammatory responses, we analyzed gene expression and protein production in human airway epithelial cells treated with some chemical components of SOAs, soluble extracts of SOAs and direct exposure to SOAs. As a result, it was suggested that treatment of epithelial cells with chemical components and soluble extracts of SOAs induced oxidative stress and inflammatory response. However, the effects differed with the type of chemical components and precursors of SOAs. Direct exposure of SOAs had no obvious effect on induction of oxidative stress and inflammatory responses.
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© 2017 Japan Automobile Research Institute
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