抄録
It has been known that strenuous physical exercise causes a rise in several growth factors. The
purpose of this study was to investigate the concentration changes of growth factors in serum, plasma
and saliva during +Gz exposures. The subjects were 12 healthy volunteers (ten males and two
females) without anti-G suit. The +Gz exposure profiles consisted of, in series, a gradual onset run
(0.1G･sec1) to the subject’s visual end-point (gray-out/black-out) or loss of consciousness, and rapid
onset run (1.0G･sec1) to the subject’s same end-point. Serum, plasma and saliva were collected
before, immediately after and 2 hours after the +Gz exposures. The concentrations of vascular
endothelial growth factor (VEGF), platelet-derived growth factor (PDGF) and transforming growth
factor-β (TGF-β) were measured using an enzyme-linked immunosorbent assay (ELISA). Significant
changes in serum VEGF, PDGF, TGF-β, plasma TGF-β and salivary PDGF were not observed during
this study. Plasma VEGF and PDGF were not detectable by using an ELISA method. Results of this
study suggest that +Gz exposures had no effect on the expression of growth factors in humans.
