Journal of Atherosclerosis and Thrombosis
Online ISSN : 1880-3873
Print ISSN : 1340-3478
ISSN-L : 1340-3478
Original Articles
Decreased Plasma Adiponectin Levels in Young Obese Males
Taketaka HaraHiroshi FujiwaraTetsuo ShojiTatsuya MimuraHayato NakaoShigeo Fujimoto
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JOURNALS OPEN ACCESS

2003 Volume 10 Issue 4 Pages 234-238

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Abstract

Plasma adiponectin levels are reduced in middle-aged obesity and in patients with type 2 diabetes and coronary artery disease. The purpose of this study was to investigate the effects of early-aged obesity on plasma adiponectin level. Twenty-six male college students (19.2 ± 1.1 years, obese group: n = 15, [body mass index > 25, percent body fat > 25%], non-obese group: n = 11) participated in the present study. We measured anthropometric parameters and plasma adiponectin and leptin level. Plasma adiponectin levels in the obese group were significantly lower than those in the non-obese group (obese: 4.7 ± 2.0 μg/ml, non-obese: 6.8 ± 2.2 μg/ml, p < 0.05). On the other hand, plasma leptin levels in the obese group were significantly higher than those in the non-obese group (obese: 8.4 ± 3.2 ng/ml, non-obese: 2.6 ± 2.1 ng/ml, p < 0.001). Plasma adiponectin levels were significantly correlated with body weight (r = − 0.415, p < 0.05) and percent body fat (r = − 0.412, p < 0.05). Stepwise multiple regression analysis revealed that percent body fat was a significant independent predictor of plasma adiponectin level (r = 0.406, p < 0.05). These results show that obesity is associated with reduced plasma adiponectin even in young subjects.

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この記事はクリエイティブ・コモンズ [表示 - 非営利 - 継承 4.0 国際]ライセンスの下に提供されています。
https://creativecommons.org/licenses/by-nc-sa/4.0/deed.ja
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