抄録
There have been a lot of studies on the correlation between hypertension and vascular lesions.
Since Winternitz and Asscher produced vascular lesions by administering kidney homogenate in dogs and rats, many kinds of experiments were attempted to separate the vasotoxic factor from the pressor substance.
In Japan too, there have been made various studies, some reported that the cause of vascular lesions in experimental hypertension is vascular permeability substance existing in the kidney and some others showed the vascular changes in the experimental animals administered with non-pressor substance of the renal cortical extracts.
The vascular necrotizing fraction was obtained by ultracentrifugation of norml rat kidney, which contained non-pressor substance in our present experiment.
Characteristic lesions 24 hours after administration of vascular necrotizing fraction of the renal extracts to bilateral nephrectomized rats were necrosis of the small arteries.
In electron microscopic observation, early vascular damage occured in medial smoth muscle cells and sometimes with serous permeation in subendothelial matrices.
Another experiment of ours was to produce the vascular lesions by freezing the renal cortex in vivo.
Vascular changes of the mesentery and intestinal tract observed in this experimental rats were similar to those lesions produced by renal cortical extracts.
By two our experments, we confirmed that the renal cortex contains necrotizing substance for vascular walls.
It seems very important to investigate the necrotizing substance extracting from the renal cortex participates in the development of the vascular lesions.
