抄録
We have already elucidated that the vascular permeability of large and medium-sized arteries in different sites vary in pattern and intensity. Therefore, when the development of atherosclerosis was considered from the standpoint of vascular permeability, there might be some difference in atherogesis between intracranial artery and aorta and/or coronary artery.
In this study, in addition to the permeability pattern of aorta and intracranial artery already reported, rabbit coronary artery was examined in respect to the fine structure and permeability pattern by using protein tracers.
1) As a distinct feature of coronary artery was there frequent presence of fenestration in the internal elastic lamina and this might contribute to the more enhanced permeability, especially by virtue of junctional transport, than aorta.
2) Long term subcutaneous injection of epinephrine induced the intimal thickening composed of smooth muscle cells where junctional transport was slightly enhanced.
3) Cholesterol feeding for 1 week, induced the enhanced junctinal transport.
4) Long term cholesterol feeding induced the foam cell lesions where both junctional and vesicular transport were enhanced.
