抄録
The inhibitory effects of HDL and HDL subfractions on the in vitro complex formation between plasma LDL and arterial elastin were studied. When a definite amount of LDL was incubated with delipidated elastin in the presence of increasing concentrations of HDL, HDL2, HDL3, HDL with E or HDL without E, the binding of LDL to elastin decreased progressively. The magnitude of inhibitory effects of HDL3 or HDL without E was greater than those of HDL2 or HDL with E, respectively. Although little effects were observed in the cases of apo HDL2 or apo HDL3 alone, the binding ability of LDL was significantly inhibited by addition of sonicated phospholipid-apoprotein complexes. Particularly, the inhibitory effect of phospholipid complex with apo HDL3 was higher than that with HDL2. In contrast with the inhibitory effect, the binding ability of HDL2 or HDL with E to delipidated elastin was significantly higher than that of HDL3 or HDL without E. These results suggest that the inhibitory effects of HDL and HDL subfractions are not due to the competitive binding to arterial elastin.
