抄録
In the present study, serum HDL2-C, HDL3-C, apo A-I, and apo A-II levels were measured in 88 diabetics to investigate the matebolism of HDL subfractions in diabetics. Diabetics were divided into three groups, taking insulin, oral agent, and diet-only.
Serum HDL2-C and HDL3-C levels were compared between each therapeutic group of diabetics and normal group. Serum HDL2-C levels in the insulin group were significantly higher than those in the normal group (p<0.01), while there was no difference between the serum HDL2-C levels in the oral agent group or diet-only group and those in the normal group. And no difference was found between the serum HDL3-C levels in each therapeutic group of diabetics and those in the normal group.
Then serum apo A-I and A-II levels were compared between each therapeutic group of diabetics and normal group. No significant differences in the serum apo A-I and apo A-II levels were found between each diabetic group and normal group. These findings suggest that in the insulin group the cholesterol/apoprotein ratio in the HDL is higher than that in the normal group.
Serum apo A-I and apo A-II levels were significantly lower in diabetics with coronary heart disease (CHD) than those in diabetics without CHD (p<0.05).
In normal subjects, HDL2-C showed a significant correlation with apo A-I (r=0.43, p<0.01), while HDL3-C demonstrated a significant correlation with apo A-I and apo A-II as well (r=0.50, p<0.01). From these results, it is guggested that HDL2 contains apo A-I, and HDL3 contains both of apo A-I and apo A-II.
