抄録
Serum HDL2- and HDL3-cholesterol (HDL2-C and HDL3-C) levels and Apoprotein A-I and A-II (Apo A-I and Apo A-II) levels were measured in 226 healthy subjects (136 males, 90 females, age ranging 20 to 79 years) and 20 neonates (10 males, 10 females). Serum lipids of the neonates were determined by umbilical cord blood.
Ultracentrifugation has been used to separate HDL and its subclasses. Apo A-I and A-II were determined by SRID method.
Results:
1) The total cholesterol (T-C) level was lowest in the newborns. In the adults, it increased with age especially in famales. As a result, females showed higher T-C values than in males in their fifties and sixties.
2) Females demonstrated higher HDL-C values than males of the same age group. This difference seemed to be caused by the difference in HDL2-C level.
3) Excluding the neonates, Apo A-I was relatively constant and showed no sex difference. The Apo A-II level was slightly higher in males than in females in the younger subjects. The Apo A-II level of the males showed a gradual decrease after the fourth decade, resulting in no apparent sex difference.
4) In the neonates, the levels of T-C, HDL-C, HDL2-C, HDL3-C, Apo A-I and Apo A-II were statistically significantly lower than any other age group. These levels of males were significantly lower than those of females.
