抄録
The aim of this study is to examine the relation between Very Low Density Lipoprotein (VLDL) apoprotein E isoforms and coronary atherosclerosis. Ninety eight subjects were allocated into two groups: 77 patients with coronary atherosclerosis (group 1) and 21 controls with normal intact coronary artery (group 2). All subjects were diagnosed by selective cornary angiography. Apoprotein E isoforms were analyzed by isoelectric focusing electrophoresis and determined semiquantitatively by densitometry.
Apo E2/E3 ratio in group 1 was significantly higher than that in group 2 (group 1: 0.60±0.20, group 2: 0.51±0.09, p<0.05: Wilcoxon's rank sum test). In group 1, 27 patients (35%) had more than 0.7 of Apo E2/E3 ratio, but all controls in group 2 had less than 0.69. The incidence of Apo E4 was 24.7% in group 1 and 23.8% in group 2, there being no singificant difference between two groups.
VLDL Apo E2/E3 ratio is clinically useful indicator of coronary aterosclerosis.
