抄録
Diabetes mellitus is frequently complicated with atherosclerosis. PWV (pulse wave velocity) is an indicator for the sclerotic change of thoratic and abdominal aorta. We studied the relation between PWV and lipid metabolism in diabetics.
The subjects who took part in this study were 54 diabetics who were aged from 50 to 59 years old and had a duration of illness over 5 years. Fasting blood sugar level and the concentration of glycosylated hemoglobin (HbA1) were measured. Serum total cholesterol (TC), triglyceride (TG), HDL-cholesterol (HDL-C), apo B and apo A-I were measured by enzymatic methods and SRID, respectively. PWV was measured by the methods of Hasegawa, et al.
We concluded that (1) PWV increased in poorly controlled diabetics (FBS 180mg/dl) more than in well controlled diabetics (FBS 119mg/dl), and (2) PWV had significant positive-relation to serum TC, TG, apo B, apo A-I and apo B/A-I ratio, and had significant negative-relation to HDL-C.
According to these data we should improve not only glucose metabolism but also derangement of lipid metabolism.
