抄録
It is our purpose to clarify the relationships among blood sugar level, serum lipids and obesity in the cases with glucose intolerance. In observation I, 40 male outpatients with diabetic type in 75g OGTT were 47.5±12.4 (M±SD) years old and were investigated for 5.1±2.3 months. They ingested 1, 626 kcal and 228g of carbohydrate per day on an average. When fasting blood sugar (FBS) decreased, serum cholesterol (Chol) decreased and triglyceride (TG), serum HDL-Cholesterol (HDL-C) or (ChoI-HDL-C)/HDL-C tended to decrease. Serum TG decreased when it's initial values were in the range from 150 to 250mg/dl.
In observation 2, 18 male outpatients with diabetic type in 75g OGTT were 46.7±10.5 years old, who showed no change or the increment of body weight for 3.2±0.8 months. They ingested 1, 599 kcal and 219g of carbohydrate.
When FBS decreased, serum cholesterol decreased and TG, HDL-C and (ChoI-HDL-C)/HDL-C tended to decrease. Serum TG decreased when it's initial values were in the range from 100 to 250mg/dl.
In observation 3, 45 male outpatients were investigated, who showed the more decreased ratio of ΔIRI/ΔBS (30 min), that was more than 0.1 in the decrement of this ratio, after about one year. 7 cases with borderline type in 50g OGTT showed the decrement of both body weight and serum TG, and tended to show the increment of HDL-C. 7 cases with the increased body weight tended to show the increment of TG. 9 cases with diabetic type showed the decrement of body weight, and tended to show the decrement of FBS, cholesterol or TG, while to show the increment of HDL-C.
In observation 4, one young female case with borderline type became hyperglycemia of 348mg/ dl in FBS, and showed the increments of serum TG (the percentage of increment 206.4%), VLDL (222.3%), NEFA (292.7%), Cholesterol (169.8%), LDL (142.3%) or β-Lipoprotein (266.4%).
From the above findings, there are suggested the relationships among FBS, TG or the change of body weight in the cases with glucose intolerance.
