抄録
To investigate the pathogenesis of vessel accidents such as myocardial infarction or angina pectoris, the following were studied,
a. The estimation of platelet aggregabilities in 36 IHDs and 24 healthy persons.
b. Periodical changes in platelet counts in 5 cases of acute myocardial infarction.
c. The changes of platelet aggregabilities with oxygen inhalation in 5 cases who required oxygen inhalation.
d. The comparison of platelet aggregabilities between arterial blood and venous blood in 5 cases with sclerotic disease.
e. The effect of CoQ10 on platelet aggregabilities in 10 patients with sclerotic disease or hypertension.
1) The platelet aggregabilities were higher in IHDs than in healthy persons.
2) The platelet counts decreased immediately after myocardial accident and thereafter increased with recovery of GOT values day by day.
3) Oxygen inhalation made platelet aggregabilities show a lower trend.
4) The platelet aggregabilities in arterial blood showed a low trend compared with venous blood.
5) The platelet aggregabilities after CoQ10 administration showed a high trend compared with those before CoQ10 administration.
Most of the IHDs have sclerosis of the coronary artery and this will induce an ischemic state due to an insufficient supply of oxygen. The ischemic state might make platelet aggregabilities higher and will make the development of myocardial infarction easier. Furthermore, it might make the IHD more advanced in vessel injury or accident.
Therefore, oxygen inhalation is useful as a treatment for patients with myocardial infarction and also the management of sclerosis is very important to prevent the development of an ischemic state.
