抄録
It has been reported that physical exercise decrease plasma-cholesterol (Ch), plasma triglyceride (TG), very low density lipoprotein (VLDL)-TG, and low density lipoprotein (LDL)-Ch in young and middle-age men. However, the effects of physical exercise on plasma lipoprotein and apolipoprotein metabolism have not been investigated in the older men. In the present study, we measured plasma concentrations of lipids, lipoproteins and apolipoproteins (apo) in 12 welltrained, older male runners. There were no significant differences in age, height and body mass index between runners and sedentary men of old and young groups. Old runner (OA) and young runner (YA) showed higher VO2 max and VO2 max/weight than old (OC) and young (YC) respective controls. There were no significant differences in plasma levels of cholesterol, triglyceride and phospholipid between two old groups and between two young groups. Runners of both old and young groups, however, had decreased levels of VLDL-and LDL-Ch, and a significantly increased levels of HDL-Ch. Among apolipoproteins, plasma apo A-I and A-II concentrations of runner were significantly higher than those of control in old group, but significant differences were not observed in young groups. Atherogenic index (LDL-Ch/HDL-Ch) of OA was significantly lower than that of OC (2.09 vs. 3.04). Atherogenic index of YA was also lower than that of YC, but differences were not significant.
Ratio of apo A-I+A-II/apo B both in runners of the old and young groups was higher than that of respective controls. Ratios of apo A-I/HDL-Ch and apo A-I+A-II/HDL-Ch in runners were significantly lower than those in controls. However, apo B/LDL-Ch was not significantly different.
Physical training significantly increased plasma HDL levels and significantly decreased plasma concentrations of LDL and VLDL. It appears that physical exercise affects more HDL-lipids than HDL-proteins. The data presented indicate that regular exercise has favorable effects on plasma concentrations of lipids, lipoproteins and apolipoproteins levels in the old runner as reported in younger runner. The effects of exercise in old-age group were greater than in younger group.
