アポ蛋白とLDLレセプター活性

抄録

The relationship of low density lipoprotein (LDL) receptor activity to plasma lipids and apolipoproteins was examined in 12 heterozygous familial hypercholesterolemia (FH) and i n 4 non- FH type II hyperlipoproteinemia. Among the factors studied, each of plasma high density lipoprotein cholesterol (HDL-C), apolipoprotein A-I, C-II and C-III levels showed a significant possitive correlation with the LDL receptor activity. A significant inverse correlation was observed between the LDL receptor activity and plasma LDL-C, apolipoprotein B, apolipoprotein B/A-I ratio and B/A-II ratio, respectively. Where-as, neither plasma total cholesterol, triglyceride, phospholipid, apolipoprotein A-II nor E levels showed any significant correlation with the LDL receptor activity.
Then we performed a multiple regression analysis, taking the LDL receptor activity as a criterion variable and plasma lipids and apolipoproteins as explanatory variables. Among many explanatory variables, plasma apolipoprotein B and C-II levels were the main determinant factors in the equation of multiple regression. In conclusion, the measurement of plasma apolipoprotein B and C-II concentration may be useful to predict the LDL receptor activity in patient with type II hyperlipoproteinemia.