Serum apo A-IV concentrations were determined in 77 patients with various types of hyperlipidemia and 34 healthy controls by means of SRID. The mean value of apo A-IV in hyperlipidemic patients was 126plusmn;42.0U/dl which was not significantly high as compared with that in controls (116±28.8U/dl). However, apo A-IV level in hyperlipidemic patients with azotemia (BUN≥20mg/dl) was significantly higher than that in those without azotemia (p7lt;0.05) and that in controls (p<0.01).
In hyperlipidemic patients with azotemia, there were significant correlations were between apo A-IV and BUN (r=0.594, p<0.01) or serum creatinine (r=0.626, p<0.01) levels, although no significant correlation was observed between apo A-IV and serum lipids (TC, TG, and HDL-C) or other apolipoproteins (apo A-I, A-II, B, C-II, C-III, and E) levels.
In view of the significant correlation between apo A-IV and BUN or serum creatinine levels, we suggest that apo A-IV levels are regulated by the degree of impairment in renal function. Therefore, it is necessary to give full consideration to evaluate the serum apo A-IV levels clinically, particularly in the case of which level shows high, because of above reason.
