抄録
Abnormal lipid metabolism has not yet been established as a risk factor of cerebral infarction. Serum lipid levels (Total cholesterol, TC; Triglyceride, TG; HDL cholesterol, HDLC; LDL cholesterol, LDLC) and apolipoproteins (apo A-I, B, E) were measured in 127 normal healthy subjects (N), 31 patients with normolipidemic hypertension (HT), 20 patients with normolipidemic diabetes mellitus (DM), and 71 patients with hyperlipidemia (HL). Ages ranged from 20 to 78 years (46.0±12.3).
Our results were as follows.
1. In N subjects, apo B and the B/A-I ratio were elevated, and the LDLC/apo B ratio was reduced with age.
2. TG and apo B were significantly elevated, and the LDLC/apo B ratio was significantly lower in the group with a family history of cerebrovascular disease (CVD).
3. In HT patients, apo B was significantly higher than in N subjects, and the LDLC/apo B ratio was significantly lower.
4. HDLC was significantly lower in DM patients than in N subjects.
5. LDLC, the Atherogenic Index (TC-HDLC/HDLC), apo B, apo E and the apo B/A-I ratio were all significantly elevated, and HDLC was significantly decreased in HL patients.
This data suggests that apo B and the LDLC/apo B ratio are useful indicators for the development of cerebral infarction.
