抄録
Probucol (250-500mg/day) was administered for five years to treat hypercholesterolemia in non-insulin dependent diabetes mellitus (NIDDM). Changes in total cholesterol, LDL-cholesterol and HDL-cholesterol levels were investigated in 120 diabetic patients (29 males and 91 females, aged between 30 and 83 years). The following results were obtained:
(1) The total-cholesterol level decreased by 45mg/dl (17%) after one year of probucol treatment and the decreased level was maintained subsequently for five years.
(2) The LDL-cholesterol level decreased by 32mg/dl (17%) after one year of probucol treatment and this decreased level was maintained subsequently for five years.
(3) Among the groups receiving only a dietary, sulfonylureas, or insulin treatment, there were no significant differences in the effects of the treatment with probucol on the serum TC, LDL-C, and HDL-C levels over a five-year period.
(4) In patients with an HDL-cholesterol level ≤40mg/dl, there was no significant decrease in the HDL-cholesterol level, although the total- and LDL-cholesterol levels were significantly decreased.
(5) No episodes of arteriosclerotic disease were newly reported during the study period. There were also no reports of adverse reactions requiring the discontinuation of probucol treatment.
These findings suggest that probucol is useful for the long-term treatment of hypercholesterolemia in NIDDM.
