抄録
We studied the occurrence of myocardial ischemia due to peripheral disturbances of coronary circulation using histological analyses and measurements of the cardiac function.
Measurements were taken for EDP, max dP/dt, max(—)dP/dt, blood pressure, pulse rate and left ventricular pressure in 10 rabbits before and after administration of a cholesterol diet for 3 months (chol rabbits), The same measurements were also taken in 5 normal rabbits. Counting was made of all the peripheral coronary arteries in diameter 50∼150 μm in which more than 75% of stenosis was observed by sectioning longitudinally every 5 mm and fibrosis % was also found.
In chol rabbits, EDP exhibited significant increases from 2.1±1.2 to 7.3±4.0 mmHg, and max(—)dP/dt exhibited significant decreases from 3, 955±583 mmHg to 3, 300±429 mmHg before and after the administration, respectively (p<0.05). No significant difference was observed in the other items, however. The main coronary artery exhibited stenosis in not more than 50% of either group, but in the chol rabbits, significant increases were observed both in the ratio of the number fo stenotic blood vessels (20.7%, 0.94%) and the fibrosis (2.71%, 1.66%).
In the chol rabbits, the increases in EDP and the decrease in max(—)dP/dt was pressumed to have resulted from peripheral coronary stenosis and associated fibrosis, and was considered to suggest the presence of myocardial ischemia.
