抄録
It is well known taht non-thrombotic cases can be seen in myocardial infarction in wide variety of frequency. In these cases coronary dysfunction was believed a priori to be the cause of myocardial necrosis without offering some reliable morphological evidenses. This type of myocardial infarction itself becomes a contradictory fact to Virchow's classical theory of mechanical (physical) obstruction of an irrigating artery“ on one hand and may give a key to solve a few difficult problems concerning myocardial infarction on the other hand; namely (1) why a maine coronary thormbus is constantly found at a very proximal portion of a coronary trunk? and (2) why the severest atherosclerosis can without exception be found at that part?
Yajima et al. could observe the “mechanical destruction and bloody imbibition” at an attaching portion of a maine thrombus to a superficial layer of an atherosclerotic intima of a coronary trunk in cases of thrombotic cases of myocardial infarction and similar usually slighter lesions at a similar portion in non-thrombotic.
These lesions were searched for by Yajima and his collaborrators based on a hypothesis of a sudden elevation of inner pressure due to derangement of systemic coronary circulation.
In this report results of observatins on prethrombotic lesions are reported and discussed. The pre-thrombotic lesions are very clearly demonstrated by electron microscopy.
