抄録
1. In in vitro experiments, low molecular weight dextran (10w/v%)(LMD) inhibited ADP-, noradrenaline- and collagen-induced human platelet aggregation. The inhibition was particularly marked for collagen-induced aggregation.
2. Administration of 250ml or 500ml of LMD with sodium lactate to normal individuals significantly inhibited platelet aggregation when determined by the screen filtration pressure method.
3. LMD exhibited significant effect to maintain red blood cell deformation ability under exaggerated conditions in vitro. Administration of 250ml or 500ml of LMD with sodium lactate tended also to increase the deformation ability in humans.
4. LMD dose-dependently inhibited release of platelet factor 3 from the platelet.
5. Use of LMD with sodium lactate in 250ml or 500ml produced no appreciable changes in clinical laboratory tests, though plasma triglyceride and cholesterol definitely decreased.
