抄録
Quantitative analysis of serum apo HDL and HDL-cholesterol was carried out in 75 human subjects. The subjects consisted of the following four groups: myocardial infarction, angina pectories, arrhythmia probably due to myocardial ischemia and normal controls. To avoid possibly indefinite factors, age matched healthy men and women who have the same occupation and have been in similar circumstances were subjected as normal control.
The concentration of apo HDL was measured by rocket immuno-electrophoresis using anti-HDL-serum (anti-α1-lipoprotein-serum, BEHR-INGWERKE AG). HDL-cholesterol was determined by the precipitation method using heparinmanganese chloride.
Mean levels of both apo HDL and HDL-cholesterol were significantly lower in two groups of myocardial infarction and angina pectoris than those in the control group. In the group of arrhythmia apo HDL level was low, but no significant decrease of HDL-cholesterol was seen.
Fourteen of 41 normal controls has low levels of HDL-cholesterol, but low levels of apo HDL were seen in only 3 control subjects.
Although there was a low statistical correlation (r=0.570, p<0.001) between apo HDL and HDL-cholesterol levels, the statistics in terms of 90% confidence interval for the regression line indicated difficulties in estimating HDL-cholesterol level from apo HDL level, i. e. the levels of HDL-cholesterol and apo HDL are variable to each other under the contribution of unknown factors.
In this study, apo HDL level was a valuable discriminator to characterize HDL abnormalities in myocardial infarction. These results bring forward an interesting problem in apo HDL metabolism, especially in atherosclerotic disease.
