抄録
When high density lipoprotein (HDL) cholesterol concentration for healthy subject was simultaneously determined by both precipitation (heparin-Ca2+ or dextran-sulfate-Mg2+) and ultracentrifugation methods, these values were well correlated with each other. In survivors of cerebral infarction, however, a considerable discrepancy was sometimes observed between HDL-cholesterol concentrations determined by the two methods. We had found three male survivors of cerebral infarction having a large difference which was subsequently confirmed on reexamination. In these patients, it was shown that HDL2:HDL3 cholesterol ratio was higher than that in healthy control and that chemical composition of HDL2 was characteristically different from that in healthy control; cholesterol content was higher and phospholipid content was lower than those of healthy control. These results suggest that such a discrepancy is due, not to inadequate precipitation conditions but rather to increased amount of abnormal lipoproteins which have a density of more than 1.063 and precipitate at the presence of polyanion and divalent cation. The most probable candidate lipoprotein may be Lp (a).
