気管支粘膜および気管支腺の病理組織学的研究

非特異性炎症性疾患

抄録

Various acute and chronic inflammatory changes of the bronchial mucosa and glands in pneumonic and bronchopneumonic lung specimens were histologically studied, comparing them with the unaffected bronchial mucosa and its glands.
Twelve lung specimens diagnosed as pneumonia or bronchopneumonia on autopsies, and forty lung specimens resected surgically as bronchiectasis were used as the material for these studies. Unaffected bronchial specimens were obtained from the lungs of premature or newborn infants or young children who died of non-pulmonary causes.
Results obtained were as follows:
In general, the inflammatory changes of the bronchial wall were more serious in the bronchopnemonic lung specimens than those in the pneumonic lung specimens.
In a case where death was due to diphtheric bronchopnemonia, besides the overlying pseudomembrane, exfoliation of cylindlic epithelium and squamous metaplasia of the mucosal epithelium were observed and in a case where death was due to measles bronchopneumonia, abundant proliferation of bronchial glands was demonstrated.
In the resected lung of bronchiectasis, squamous metaplasis of the mucosal epithelium had predominantly developed in the bronchial mucosa with severe acute submucosal inflammation, and a marked development of the bronchial glands and vivid proliferation of goblet cells were frequently observed in the bronchial mucosa with less inflammatory processes and much fibrotic proliferation.
Dilated bronchial veins, necrobiotic cartilages, abnormal arrangements of the muscular layers, development of fat tissue and lymphatic follicles with germinal centers were occasionally found in the bronchial mucosa of dilated bronchi, and in six cases of bronchiectasis, asthenia of the components of the bronchial wall was recognized.