1968 年 19 巻 6 号 p. 295-312,273
Silicon sands, carbon grains of red clay particles were given 240 guinea pigs respectively with an inspirator for duration from one hour to 16 days for 6 hours a day. After inspiration, the respiratory organ of the each animals were examined histopathologically.
With extend the piriod of inspiration, degeneration in the organ became remarkably. Damages of the lung were most severely; bleeding, edema and cellular infiltration were found. In the bronchus and trachea, cellular infiltration and epithelial tear were observed. Slight degeneration was found in the pharyngolarynx; cellular infiltration and partiallary capillary dilatation were observed.