気管支喘息の病態生理に関する研究

とくに非発作時と発作時における気管支動態像の変化を中心として

抄録

The bronchial dynamic findings were studied in patients with bronchial asthma and dogs with model of asthma using bronchography, bronchoscopy and pulmonary function study in non-attack and attack periods.
Varous abnormal findings, most of them showed constriction, were obtained on bronchography in attack periods and the abnormalities were somewhat different from each other according to the types of asthma, but some changes were observed in non-attack periods.
The abnormal findings were correlated with FEV _1.0.
Typical asthmatic condition was produced in dogs by the inhalation of histamine, acetylcholine or methacholine. It was very similar to the clinical findings of asthma.
Various bronchial changes in the dogs with model of asthma were observed in process of time.
There were a little difference among the effects induced by each drugs.